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1

Mechanisms for membrane transport of metformin in human intestinal epithelial Caco-2 cells

Asuka Horie, Jumpei Sakata, Maki Nishimura, Kazuya Ishida, Masato Taguchi, Yukiya Hashimoto

Journal:

Biopharmaceutics & Drug Disposition

Year:

2011

Language:

english

File:

PDF, 501 KB

english, 2011

2

Effects of Intestinal and Hepatic Metabolism on the Bioavailability of Tacrolimus in Rats

Yukiya Hashimoto, Hiroaki Sasa, Masahiro Shimomura, Ken-ichi Inui

Journal:

Pharmaceutical Research

Year:

1998

File:

PDF, 420 KB

1998

3

Pharmacokinetics and Bioavailability of Tacrolimus in Rats with Experimental Renal Dysfunction

HIROMI OKABE, YUKIYA HASHIMOTO, KEN-ICHI INUI

Journal:

Journal of Pharmacy and Pharmacology

Year:

2000

Language:

english

File:

PDF, 77 KB

english, 2000

4

Inhibitory effect of anti-diabetic agents on rat organic anion transporter rOAT1

Yuichi Uwai, Hideyuki Saito, Yukiya Hashimoto, Ken-ichi Inui

Journal:

European Journal of Pharmacology

Year:

2000

Language:

english

File:

PDF, 149 KB

english, 2000

5

A Case of Spontaneous Regression of Primary Malignant Lymphoma of the Stomach

Kazuo HAYAKAWA, Sohtaro FUKUCHI, Yukiya YOSHIDA, Mitsuyo HASHIMOTO, Yoshio HOSHIHARA, Shigesaburo MIYAKOSHI, Kyoo NANAUMI, Masamitsu UNAKAMI

Journal:

Digestive Endoscopy

Year:

1992

Language:

english

File:

PDF, 2.57 MB

english, 1992

6

Membrane transport mechanisms of choline in human intestinal epithelial LS180 cells

Horie, Asuka, Ishida, Kazuya, Watanabe, Yuri, Shibata, Kaito, Hashimoto, Yukiya

Journal:

Biopharmaceutics & Drug Disposition

Year:

2014

Language:

english

File:

PDF, 437 KB

english, 2014

7

Multiple Regression Analysis of Pharmacogenetic Variability of Carvedilol Disposition in 54 Healthy Japanese Volunteers

Honda, Mutsuko, Ogura, Yumi, Toyoda, Wakako, Taguchi, Masato, Nozawa, Takashi, Inoue, Hiroshi, Hashimoto, Yukiya

Journal:

Biological & Pharmaceutical Bulletin

Year:

2006

Language:

english

File:

PDF, 199 KB

english, 2006

8

Mechanisms responsible for the altered pharmacokinetics of Bosentan: analysis utilizing rats with bile duct ligation-induced liver dysfunction

Isao Horiuchi, Yun-i Mori, Masato Taguchi, Fukiko Ichida, Toshio Miyawaki, Yukiya Hashimoto

Journal:

Biopharmaceutics & Drug Disposition

Year:

2009

Language:

english

File:

PDF, 105 KB

english, 2009

9

Temperature-dependent specific transport of levofloxacin in human intestinal epithelial LS180 cells

Shiro Fukumori, Miki Masago, Kazuya Ishida, Yuichiro Kayano, Masato Taguchi, Yukiya Hashimoto

Journal:

Biopharmaceutics & Drug Disposition

Year:

2009

Language:

english

File:

PDF, 262 KB

english, 2009

10

Genetic polymorphism of the CYP2C subfamily and its effect on the pharmacokinetics of phenytoin in Japanese patients with epilepsy*

Odani, Atsuko, Hashimoto, Yukiya, Otsuki, Yuko, Uwai, Yuichi, Hattori, Haruo, Furusho, Kenshi, Inui, Ken-ich

Journal:

Clinical Pharmacology & Therapeutics

Year:

1997

Language:

english

File:

PDF, 598 KB

english, 1997

11

Synthesis of d1-aspterric acid, a carotane type sesquiterpene

Takashi Harayama, Yutaka Shinkai, Yukiya Hashimoto, Hideto Fukushi, Yasuo Inubushi

Journal:

Tetrahedron Letters

Year:

1983

Language:

english

File:

PDF, 213 KB

english, 1983

12

A simulation study comparing designs for dose ranging

Lewis B. Sheiner, Yukiya Hashimoto, Stuart L. Beal

Journal:

Statistics in Medicine

Year:

1991

Language:

english

File:

PDF, 1.12 MB

english, 1991

13

Effect ofCYP2D6*10on pharmacokinetic variability of routinely administered metoprolol in middle-aged and elderly Japanese patients

Masato Taguchi, Takashi Nozawa, Tomoki Kameyama, Hiroshi Inoue, Chihiro Takesono, Akiko Mizukami, Yukiya Hashimoto

Journal:

European Journal of Clinical Pharmacology

Year:

2003

Language:

english

File:

PDF, 272 KB

english, 2003

14

Structural requirements for determining the substrate affinity of peptide transporters PEPT1 and PEPT2

Tomohiro Terada, Kyoko Sawada, Megumi Irie, Hideyuki Saito, Yukiya Hashimoto, Ken-ichi Inui

Journal:

Pflügers Archiv European Journal of Physiology

Year:

2000

Language:

english

File:

PDF, 126 KB

english, 2000

15

Population pharmacokinetics of mizoribine in adult recipients of renal transplantation

Kazuya Ishida, Masahiko Okamoto, Michio Ishibashi, Yukiya Hashimoto

Journal:

Clinical and Experimental Nephrology

Year:

2011

Language:

english

File:

PDF, 301 KB

english, 2011

16

A case of incidentally detected IgG4-related sclerosing disease involving inflammatory abdominal aortic aneurysm and autoimmune pancreatitis

Yasunori Matsuki, Kimiya Sato, Akira Fujikawa, Yukishige Kyoto, Hiroshi Hashimoto, Yukiya Hakozaki

Journal:

Modern Rheumatology

Year:

2010

Language:

english

File:

PDF, 311 KB

english, 2010

17

Effects of glibenclamide on glycylsarcosine transport by the rat peptide transporters PEPT1 and PEPT2

Kyoko Sawada, Tomohiro Terada, Hideyuki Saito, Yukiya Hashimoto, Ken-ichi Inui

Journal:

British Journal of Pharmacology

Year:

1999

Language:

english

File:

PDF, 244 KB

english, 1999

18

Transepithelial Transport of Levofloxacin in the Isolated Perfused Rat Kidney

Tatsuya Ito, Ikuko Yano, Yukiya Hashimoto, Ken-ichi Inui

Journal:

Pharmaceutical Research

Year:

2000

Language:

english

File:

PDF, 232 KB

english, 2000

19

N-terminal Halves of Rat H+/Peptide Transporters Are Responsible for Their Substrate Recognition

Tomohiro Terada, Hideyuki Saito, Kyoko Sawada, Yukiya Hashimoto, Ken-ichi Inui

Journal:

Pharmaceutical Research

Year:

2000

Language:

english

File:

PDF, 90 KB

english, 2000

20

Transepithelial Transport of Diphenhydramine Across Monolayers of the Human Intestinal Epithelial Cell Line Caco-2

Hiroshi Mizuuchi, Toshiya Katsura, Yukiya Hashimoto, Ken-ichi Inui

Journal:

Pharmaceutical Research

Year:

2000

Language:

english

File:

PDF, 171 KB

english, 2000

21

Transport of Levofloxacin in the OK Kidney Epithelial Cell Line: Interaction with p-Aminohippurate Transport

Yumiko Matsuo, Ikuko Yano, Yasushi Habu, Toshiya Katsura, Yukiya Hashimoto, Ken–ichi Inui

Journal:

Pharmaceutical Research

Year:

2001

Language:

english

File:

PDF, 203 KB

english, 2001

22

Effects of Arbekacin and Vancomycin on Release of Lactate Dehydrogenase and Fragmentation of DNA in LLC-PK1 Kidney Epithelial Cells

Tsutomu Nakamura, Toshiyuki Kokuryo, Masahiro Okuda, Yukiya Hashimoto, Ken-Ichi Inui

Journal:

Pharmaceutical Research

Year:

1999

File:

PDF, 1.34 MB

1999

23

Effect of Neutral Endopeptidase Inhibition on the Natriuresis and Renal Clearance of Atrial Natriuretic Peptide in Perfused Rat Kidney

Masayuki Yamaguchi, Yukiya Hashimoto, Hiroshi Itoh, Kazuwa Nakao, Ken-ichi Inui

Journal:

Pharmaceutical Research

Year:

1998

File:

PDF, 318 KB

1998

24

Effects of Fosfomycin and Imipenem/ Cilastatin on Nephrotoxicity and Renal Excretion of Vancomycin in Rats

Tsutomu Nakamura, Yukiya Hashimoto, Toshiyuki Kokuryo, Ken-Ichi Inui

Journal:

Pharmaceutical Research

Year:

1998

File:

PDF, 474 KB

1998

25

Kinetic Analysis of Tetraethylammonium Transport in the Kidney Epithelial Cell Line, LLC-PK1

Yoshiko Tomita, Yuko Otsuki, Yukiya Hashimoto, Ken-ichi Inui

Journal:

Pharmaceutical Research

Year:

1997

File:

PDF, 386 KB

1997

26

Simulation for Population Pharmacodynamic Analysis of Dose-Ranging Trials: Usefulness of the Mixture Model Analysis for Detecting Nonresponders

Takeshi Shiiki, Yukiya Hashimoto, Ken-ichi Inui

Journal:

Pharmaceutical Research

Year:

2002

Language:

english

File:

PDF, 81 KB

english, 2002

27

Distribution Characteristics of Levofloxacin and Grepafloxacin in Rat Kidney

Tatsuya Ito, Ikuko Yano, Satohiro Masuda, Yukiya Hashimoto, Ken-ichi Inui

Journal:

Pharmaceutical Research

Year:

1999

File:

PDF, 895 KB

1999

28

Natriuretic Peptide-Potentiating Actions of Neutral Endopeptidase Inhibition in Rats with Experimental Heart Failure

Masato Yasuhara, Masayuki Yamaguchi, Hiromasa Shimizu, Yukiya Hashimoto, Norio Hama, Hiroshi Itoh, Kazuwa Nakao, Ryohei Hori

Journal:

Pharmaceutical Research

Year:

1994

File:

PDF, 879 KB

1994

29

Simulation for the Analysis of Distorted Pharmacodynamic Data

Yukiya Hashimoto, Junko Ozaki, Toshiko Koue, Atsuko Odani, Masato Yasuhara, Ryohei Hori

Journal:

Pharmaceutical Research

Year:

1994

File:

PDF, 722 KB

1994

30

Clearance Mechanisms of Atrial and Brain Natriuretic Peptides in Rats

Yukiya Hashimoto, Kazuwa Nakao, Norio Hama, Hiroo Imura, Sachiyo Mori, Masayuki Yamaguchi, Masato Yasuhara, Ryohei Hori

Journal:

Pharmaceutical Research

Year:

1994

File:

PDF, 931 KB

1994

31

p-Aminohippurate Transport at the Apical Membrane in the OK Kidney Epithelial Cell Line

Yasushi Habu, Ikuko Yano, Yukiya Hashimoto, Hideyuki Saito, Ken-ichi Inui

Journal:

Pharmaceutical Research

Year:

2002

Language:

english

File:

PDF, 91 KB

english, 2002

32

Effects of Fosfomycin and Imipenem-Cilastatin on the Nephrotoxicity of Vancomycin and Cisplatin in Rats

TSUTOMU NAKAMURA, TOSHIYUKI KOKURYO, YUKIYA HASHIMOTO, KEN-ICHI INUI

Journal:

Journal of Pharmacy and Pharmacology

Year:

1999

Language:

english

File:

PDF, 87 KB

english, 1999

33

Evaluation of increased bioavailability of tacrolimus in rats with experimental renal dysfunction

Hiromi Okabe, Ikuko Yano, Yukiya Hashimoto, Hideyuki Saito, Ken-ichi Inui

Journal:

Journal of Pharmacy and Pharmacology

Year:

2002

Language:

english

File:

PDF, 172 KB

english, 2002

34

The increased intestinal absorption rate is responsible for the reduced hepatic first-pass extraction of propranolol in rats with cisplatin-induced renal dysfunction

Hiromi Okabe, Akiko Mizukami, Masato Taguchi, Tetsuya Aiba, Masato Yasuhara, Yukiya Hashimoto

Journal:

Journal of Pharmacy and Pharmacology

Year:

2003

Language:

english

File:

PDF, 242 KB

english, 2003

35

Nonlinear mixed effect modeling of the pharmacodynamics of natriuretic peptides in rats

Yukiya Hashimoto, Sachiyo Mori, Norio Hama, Kazuwa Nakao, Hiroo Imura, Masayuki Yamaguchi, Masato Yasuhara, Ryohei Hori

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

1993

Language:

english

File:

PDF, 839 KB

english, 1993

36

Kinetics of ajmaline disposition and pharrnacologic response in beagle dogs

Masato Yasuhara, Yukiya Hashimoto, Katsuhiko Okumura, Ryohei Hori, Tsunetaro Sakurai, Chuichi Kawai

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

1987

Language:

english

File:

PDF, 870 KB

english, 1987

37

Simulation for population analysis of Michaelis-Menten elimination kinetics

Yukiya Hashimoto, Toshiko Koue, Yuko Otsuki, Masato Yasuhara, Ryohei Hori, Ken-ichi Inui

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

1995

Language:

english

File:

PDF, 626 KB

english, 1995

38

Designs for population pharmacodynamics: Value of pharmacokinetic data and population analysis

Yukiya Hashimoto, Lewis B. Sheiner

Journal:

Journal of Pharmacokinetics and Pharmacodynamics

Year:

1991

Language:

english

File:

PDF, 945 KB

english, 1991

39

Functional evidence for an apical ANP receptor in LLC-PK1 kidney epithelial cells

Yukiya Hashimoto, Junko Ozaki, Masato Yasuhara, Ryohei Hori, Shin-ichi Suga, Hiroshi Itoh, Kazuwa Nakao, Ken-inchi Inui

Journal:

European Journal of Pharmacology: Molecular Pharmacology

Year:

1994

Language:

english

File:

PDF, 319 KB

english, 1994

40

Contribution of Na+-independent nucleoside transport to ribavirin uptake in the rat intestine and human epithelial LS180 cells

Mari Takaai, Hiroki Morishita, Kazuya Ishida, Masato Taguchi, Yukiya Hashimoto

Journal:

European Journal of Pharmacology

Year:

2008

Language:

english

File:

PDF, 581 KB

english, 2008

41

Role of apoptosis in cisplatin-induced toxicity in the renal epithelial cell line LLC-PK1: Implication of the functions of apical membranes

Masahiro Okuda, Koichi Masaki, Sachio Fukatsu, Yukiya Hashimoto, Ken-ichi Inui

Journal:

Biochemical Pharmacology

Year:

2000

Language:

english

File:

PDF, 425 KB

english, 2000

42

Inhibitory effect of novel oral hypoglycemic agent nateglinide (AY4166) on peptide transporters PEPT1 and PEPT2

Tomohiro Terada, Kyoko Sawada, Hideyuki Saito, Yukiya Hashimoto, Ken-ichi Inui

Journal:

European Journal of Pharmacology

Year:

2000

Language:

english

File:

PDF, 322 KB

english, 2000

43

Enzymatic inactivation of major circulating forms of atrial and brain natriuretic peptides

Junko Ozaki, Hiromasa Shimizu, Yukiya Hashimoto, Hiroshi Itoh, Kazuwa Nakao, Ken-ichi Inui

Journal:

European Journal of Pharmacology

Year:

1999

Language:

english

File:

PDF, 213 KB

english, 1999

44

Inhibitory effect of KW-3902, an adenosine A1 receptor antagonist, on p-aminohippurate transport in OK cells

Junya Nagai, Ikuko Yano, Yasushi Habu, Toshiya Katsura, Yukiya Hashimoto, Ken-ichi Inui

Journal:

Biochimica et Biophysica Acta (BBA) - Biomembranes

Year:

1999

Language:

english

File:

PDF, 267 KB

english, 1999

45

Functional characterization of the rat multispecific organic anion transporter OAT1 mediating basolateral uptake of anionic drugs in the kidney

Yuichi Uwai, Masahiro Okuda, Kenji Takami, Yukiya Hashimoto, Ken-ichi Inui

Journal:

Year:

1998

Language:

english

File:

PDF, 139 KB

english, 1998

46

Functional analysis of rat renal organic anion transporter OAT-K1: bidirectional methotrexate transport in apical membrane

Satohiro Masuda, Ayako Takeuchi, Hideyuki Saito, Yukiya Hashimoto, Ken-ichi Inui

Journal:

Year:

1999

Language:

english

File:

PDF, 181 KB

english, 1999

47

Gender differences in expression of organic cation transporter OCT2 in rat kidney

Yumiko Urakami, Nobuhiko Nakamura, Kazushige Takahashi, Masahiro Okuda, Hideyuki Saito, Yukiya Hashimoto, Ken-ichi Inui

Journal:

Year:

1999

Language:

english

File:

PDF, 130 KB

english, 1999

48

Pharmacokinetics and antiarrhythmic activity of ajmaline in rats subjected to coronary artery occlusion

Yukiya Hashimoto, Ryohei Hori, Katsuhiko Okumura, Masato Yasuhara

Journal:

British Journal of Pharmacology

Year:

1986

Language:

english

File:

PDF, 909 KB

english, 1986

49

Regional myocardial ajmaline concentration and antiarrhythmic activity for ischaemia- and reperfusion-induced arrhythmias in rats

Katsuhiko Okumura, Yukiya Hashimoto, Masato Yasuhara, Ryohei Hori

Journal:

British Journal of Pharmacology

Year:

1988

Language:

english

File:

PDF, 858 KB

english, 1988

50

Pharmacokinetics and dromotropic activity of ajmaline in rats with hyperthyroidism

Yukiya Hashimoto, Masato Yasuhara, Akira Kamiya, Katsuhiko Okumura, Ryohei Hori

Journal:

British Journal of Pharmacology

Year:

1989

Language:

english

File:

PDF, 959 KB

english, 1989

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